Several blinded studies show no such effects when MSG is combined with food in normal concentrations, and are inconclusive when MSG is added to broth in large concentrations. The European Union classifies it as a food additive permitted in certain foods and subject to quantitative limits. MSG has the HS code 29224220 and the E number E621. Pure MSG is reported not to have a highly pleasant taste until it is combined with a savory aroma.

The basic sensory function of MSG is attributed to its ability to enhance savory taste-active compounds when added in the proper concentration. The optimal concentration varies by food in clear soup, the 'pleasure score' rapidly falls with the addition of more than one gram of MSG per 100 mL. The sodium content (in mass percent) of MSG, 12.28%, is about one-third of that in sodium chloride (39.34%), due to the greater mass of the glutamate counterion.

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